Formulation, Physicochemical Evaluation and Antimicrobial Activity of a Polyherbal Topical Cream Containing Tridax procumbens, Aloe vera, Curcuma longa and Mentha spp.
Author : Suraj Gabale, Shweta Pise-Atigre, Aishwarya Kadake, Kedar Rajput, Karisma Vast and Akshata Parit
Abstract :
This study aimed to formulate and evaluate a polyherbal topical cream containing Tridax procumbens, Aloe vera, Curcuma longa, and Mentha spp. for antimicrobial skincare applications. An oil-in-water emulsion was prepared using beeswax and liquid paraffin as the base. Physicochemical parameters including pH, viscosity, spreadability, phase stability, and skin irritation were evaluated. Antimicrobial activity was assessed against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumoniae, and Candida albicans using the agar well diffusion method.
The cream exhibited good homogeneity, stability without phase separation, suitable pH (7.68–7.97), and no skin irritation. Significant antimicrobial activity was observed, with maximum inhibition zones of 25 mm against Klebsiella pneumoniae and Candida albicans. Preliminary phytochemical analysis revealed the presence of flavonoids and phenolic compounds, which may contribute to the antimicrobial effect.
The developed polyherbal cream demonstrates promising antimicrobial potential, acceptable physicochemical stability, and suitability for topical use. Further studies on long-term stability and clinical efficacy are recommended.
Keywords :
Polyherbal cream, Topical formulation, Antimicrobial activity, Herbal cosmetics, Tridax procumbens.
