Comprehensive Review on Rate Control Drug Delivery Systems (RCDDS)
Author : Rohan Khandu Kamble and Manjusha Vasantrao Kadam
Abstract :
A Rate controlled drug delivery system is used to release an active pharmaceutical ingredient and attain the intended healing outcome. RCDDS addresses the drawbacks of traditional drug delivery systems, such as pills, capsules, syrups, and ointments. These approaches usually have low bioavailability, fluctuating plasma drug levels, and cannot deliver constant release. An effectively designed controlled-release drug delivery system can considerably improve the ability to target a medicine while also regulating the rate of drug administration to the targeted region. CDDS can deliver drugs locally or systemically at a predetermined rate and time. These systems, which usually exhibit zero-order release kinetics, control the drug's plasma concentration after delivery via a number of channels and release the drug in a planned pattern over a set time period.
By optimizing a drug's pharmacokinetic, pharmacodynamic, and biopharmaceutical properties via controlled release, the frequency of dosage can be minimized possibly to a once at a day while maintaining a steady plasma concentration. This strategy promotes patient compliance by increasing the drug's usefulness, reducing systemic and local side effects, and treating or controlling issues more quickly with fewer dosages.
Keywords :
Controlled release, drug concentration, dose frequency, pharmacokinetics, bioavailability, target delivery, etc.
