Role of Serum Ferritin and Thrombocytopenia in Febrile Illness-Dengue: A Hospital Based Cross Sectional Study
Author : Dr. Abishek Chakkaravarthi Moorthy
Abstract :
The Dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) and the rare macrophage activation syndrome (MAS) are major causes of morbidity and mortality in many endemic Asian and South American countries. Increased serum ferritin levels have been proven to be helpful in predicting disease severity with a high sensitivity and specificity. Since the 1990s, epidemics of dengue have become more frequent in numerous parts of India.
Ferritin is a positive acute phase reactant, synthesized and secreted in hepatocytes, macrophages and cancer cells. Hyperferritinemia and platelet indices can be used to fulfill this criteria, and estimate severity of the disease in it’s clinical course.
70 cases of serology positive dengue patients from the Sree Balaji medical college hospital were selected for this study. Venous blood was collected with minimal stasis using dry and disposable syringe and needle.
Calculations were done using SPSS21 and Microsoft excel. One way analysis of variance (ANOVA) with post-hoc test. Turkey's honest significance difference tests, Spearman’s Rho Correlation, Chi-square test of independence were used to compare more than two independent samples. T-test for single samples was done. P 0.05(a=0.05) were considered to be statistically significant.
Keywords :
Dengue, ferritin, biomarkers, morbidity and mortality
