Piper longum Extracts Impairs Larval Locomotion in Drosophila melanogaster
Author : Priyadarshiniraj N and Dr. V Shakunthala
Abstract :
This study investigates the neuromuscular basis of crawling behavior in Drosophila melanogaster larvae, focusing on the effects of genetic manipulation and environmental stressors. By examining the rectilinear crawling behavior of third instar larvae, we aimed to understand the motor patterns underlying this vital locomotion process. The larvae, which move through peristaltic waves of muscle contraction and relaxation, were analyzed using a range of experimental probes addressing molecular, cellular, genetic, and behavioral aspects. Our results demonstrate that specific genetic alterations, such as gene expression or elimination, significantly impact larval crawling behavior, particularly in conditions leading to fatality in pupal or adult stages. Additionally, we observed that combining this assay with environmental stressors like intense light can further elucidate the behavioral responses of Drosophila larvae. These findings contribute to a deeper understanding of the fundamental neuromuscular mechanisms in Drosophila and provide insights into the development of phytochemical-based treatments for neurological conditions such as Parkinson’s and Alzheimer’s disease.
Keywords :
Crawling, neuromuscular, Drosophila melanogaster, Piper longum
