A Review of Formulation Floating Drug Delivery System: Based Technique by Solid Dispersion
Author : Anjali Rathore, Dr. Narendra Mandoriya, Dr. Dharmesh Sisodiya and Dr. Kamlesh Dashora
Abstract :
The present study aimed at development of Tinidazole floating tablets to enhance drug solubility and bioavailability. Tinidazole, a BCS Class-II drug with poor aqueous solubility, faces challenges in achieving predictable in vivo correlations and suffers from low and variable bioavailability due to extensive first-pass effects. Solid dispersions using PEG6000, PVP K30, and PXM 188 were prepared and characterized. The batch (SD9) with PXM 188 (1:3) showed better release profiles and was selected for effervescent tablet formulation. Drug free effervescent tablets (F4) were optimized using Box behnken response surface design and demonstrated optimal floating characteristics. Granules were found to be within acceptable ranges for bulk density, tap density, and angle of repose. Floating tablets of tinidazole were made by direct compression and subjected to a battery of tests. Formulation A3, which had a 1:1.5% ratio of HPMC to carbopol, showed promising results in terms of floating time, drug content, and drug release profile. After 12 hours, the drug release rate was around 91.56%, and the floating time was 7 hours, making formulation (A3) the best option. The research found that a combination of sodium bicarbonate as a gas producing agent and HPMC: Carbopol may be effectively employed to create Tinidazole sustained release floating tablets.
Keywords :
Tinidazole, box behnken design, solid dispersions, PEG6000, carbopol, floating tablets
