Synthesis and Biological Evaluation of Novel Variants of Pyridyl Thiazoles for Antimicrobial, Anti-Candidal and Anti-Mycobacterial Activity
Author : Dr. Manjusha Suryawanshi, Patil Amar A, Sharma Lokesh P, Bhawsar Swati P and Chikhale Hemant U
Abstract :
Background: Thiazoles are one of the most studied 5-membered aromatic heterocyclic. Many natural and synthetic thiazoles, as well as their derivatives, exhibited biological activity. Thiazole derivatives have antibacterial action against a variety of bacteria and diseases due to their unique characteristics. Because of its immense biological significance, scientists are working hard to develop novel biologically active thiazole compounds.
Method: In the present study the synthesis of some derivatives of the 2-pyridyl/3-pyridyl and 4-pyridyl substituent at C-2, and the aryl substituent at C-2 (Scheme 1) design and the desired target molecules 2a-2g, 3a-3g and 4a-4g were synthesized via the classic Hantzsch thiazole synthesis.
Result: The synthesized compounds were confirmed on the basis of IR, 1H-NMR and Mass analyses. The newly synthesized compounds were evaluated for their Antimicrobial, Anti-Candidal and Anti-Mycobacterial Activity by S. aureus and E. coli; Anticandidal activity of test compound was assessed against Candida albicans and Mycobacterium smegmatis for Anti-Mycobacterial Activity.
Conclusion: The biological importance of pyridyl-thiazole derivatives is reported here in the clubbed pyridyl-thiazole derivatives as possible antimycobacterial drugs, as part of our hunt for new antitubercular medicines.
Keywords :
Antimicrobial, anti-candidal, anti-mycobacterial, pyridyl thiazole
