Mechanistic Insights into the Cytoprotective Effects of 3, 4, 5-Trihydroxybenzoic Acid on Carbon Tetrachloride-Induced Liver Injury
Author : Dr. Anjana Jadon
Abstract :
The hepatoprotective activity of the alcoholic extract of Terminalia belerica (TB) and its active principle i.e. 3, 4, 5-trihydroxybenzoic acid: Gallic acid (GA) has been studied against carbon tetrachloride induced liver toxicity. Carbon tetrachloride (1.5 ml/kg i.p.) caused significant increase in the activities of serum alkaline phosphatase and serum transaminases. Serum protein content elevated significantly after CCl4 administration. A significant increased was observed in hepatic lipid peroxidation while a considerable fall was found in reduced glutathione after toxicant administration. These altered parameters were significantly restored with the therapy of active principle (200 mg/kg p.o.) whereas extract therapy (400 mg/kg p.o.) comparatively less effective. The effects of therapeutic agents on BSP clearance test indicated its protective role. Carbon tetrachloride caused severe degeneration, disturbed chord arrangement and focal necrosis in hepatocytes were also seen. Recoupment were seen in histological alterations by therapy with extract and active principle but the degree of protection conferred by active principle was more as compared to extract. The extract per se and active principle per se did not show any sign of toxicity.
Keywords :
Terminalia belerica (TB), carbon tetrachloride, Active principle (AP).
